The role of nuclear Y-box binding protein 1 as a global marker in drug resistance

Michihiko Kuwano; Yoshinao Oda; Hiroto Izumi; Song Ju Yang; Takeshi Uchiumi; Yukihide Iwamoto; Masakazu Toi; Teruhiko Fujii; Hideaki Yamana; Hisafumi Kinoshita; Toshiharu Kamura; Masazumi Tsuneyoshi; Kosei Yasumoto; Kimitoshi Kohno

doi:10.1158/1535-7163.1485.3.11

The role of nuclear Y-box binding protein 1 as a global marker in drug resistance

Michihiko Kuwano, Yoshinao Oda, Hiroto Izumi, Song Ju Yang, Takeshi Uchiumi, Yukihide Iwamoto, Masakazu Toi, Teruhiko Fujii, Hideaki Yamana, Hisafumi Kinoshita, Toshiharu Kamura, Masazumi Tsuneyoshi, Kosei Yasumoto, Kimitoshi Kohno

Research output: Contribution to journal › Short survey › peer-review

129 Citations (Scopus)

Abstract

Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

Original language	English
Pages (from-to)	1485-1492
Number of pages	8
Journal	Molecular cancer therapeutics
Volume	3
Issue number	11
DOIs	https://doi.org/10.1158/1535-7163.1485.3.11
Publication status	Published - Nov 2004

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1535-7163.1485.3.11

Cite this

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abstract = "Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.",

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AU - Kuwano, Michihiko

AU - Oda, Yoshinao

AU - Izumi, Hiroto

AU - Yang, Song Ju

AU - Uchiumi, Takeshi

AU - Iwamoto, Yukihide

AU - Toi, Masakazu

AU - Fujii, Teruhiko

AU - Yamana, Hideaki

AU - Kinoshita, Hisafumi

AU - Kamura, Toshiharu

AU - Tsuneyoshi, Masazumi

AU - Yasumoto, Kosei

AU - Kohno, Kimitoshi

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N2 - Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

AB - Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

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The role of nuclear Y-box binding protein 1 as a global marker in drug resistance

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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