TY - JOUR
T1 - THE ROLE OF HLA CLASS II ANTIGENS IN THE INDUCTION OF CYTOTOXIC T LYMPHOCYTES
AU - Demeŝová, V.
AU - Buc, M.
AU - Ferenĉiak, S.
AU - Sasazuki, T.
AU - Shawkatová, I.
AU - PORUBSKA, S.
PY - 1995/12
Y1 - 1995/12
N2 - Investigation of pairs of unrelated persons mismatched for a particular HLA‐DQB1 or ‐DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA‐DQ and HLA‐DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti‐DQ and anti‐DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA‐DQ and HLA‐DP antigens play a similar role to HLA‐DR specificities in clinical bone marrow transplantation.
AB - Investigation of pairs of unrelated persons mismatched for a particular HLA‐DQB1 or ‐DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA‐DQ and HLA‐DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti‐DQ and anti‐DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA‐DQ and HLA‐DP antigens play a similar role to HLA‐DR specificities in clinical bone marrow transplantation.
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U2 - 10.1111/j.1744-313X.1995.tb00280.x
DO - 10.1111/j.1744-313X.1995.tb00280.x
M3 - Article
C2 - 8597559
AN - SCOPUS:0028882716
SN - 1744-3121
VL - 22
SP - 425
EP - 434
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
IS - 6
ER -