The role of glucocorticoids and retinoic acid in the pituitary endocrine cell differentiation

Kinji Inoue, Hideki Goda, Chihiro Mogi, Mikio Tomida, Shinobu Tsurugano

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Anterior pituitary hormones are individually produced and secreted by five types of glandular cells. These specialized types of cells, which produce different hormones, are believed to arise from common stem cells. However, the mechanism by which these anterior pituitary glandular cells differentiate is still under discussion. Recent advances in molecular biology have revealed many transcription factors that promote pituitary hormone gene expression. The Pit-1 gene is an example of such a transcription factor. The Pit-1 gene is known to affect growth hormone (GH), prolactin (PRL), and thyrotropin (TSH) cell differentiation. This suggests that all three cell types may arise from a common progenitor cell. However, how these cell types differentiate and then mature into individual cell types in the adult anterior pituitary gland is still unknown. We were especially interested in the differentiation of Pit-1 lineage cells.

Original languageEnglish
Title of host publicationNeuroplasticity, Development, and Steroid Hormone Action
PublisherCRC Press
Pages73-80
Number of pages8
ISBN (Electronic)9781420041194
ISBN (Print)084930962X, 9780849309625
Publication statusPublished - Jan 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology

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