TY - JOUR
T1 - The role of DNA repair glycosylase OGG1 in intrahepatic cholangiocarcinoma
AU - Sakata, Kazuhito
AU - Yoshizumi, Tomoharu
AU - Izumi, Takuma
AU - Shimokawa, Masahiro
AU - Itoh, Shinji
AU - Ikegami, Toru
AU - Harada, Noboru
AU - Toshima, Takeo
AU - Mano, Yohei
AU - Mori, Masaki
N1 - Publisher Copyright:
© 2019 International Institute of Anticancer Research. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background/Aim: The effects of oxidative stress on various carcinomas were reported in previous studies, but those in intrahepatic cholangiocarcinoma (ICC) have not been fully elucidated. The purpose of this study was, thus, to reveal the effects of oxidative DNA damage and repair enzymes on ICC. Materials and Methods: The levels of 8-hydroxydeoxyguanosine (8-OHdG) and 8-OHdG DNA glycosylase (OGG1) were immunohistochemically evaluated in specimens resected from 63 patients with ICC. Results: Low OGG1 expression was related to tumour depth T4 (p=0.04), venous invasion (p=0.0005), lymphatic vessel invasion (p=0.03), and perineural invasion (p=0.03). Compared to the high-OGG1-expression group, patients with low OGG1 expression had a significantly poorer prognosis (overall survival: p=0.04, recurrence-free survival: p=0.02). Unlike for OGG1, the expression levels of 8-OHdG showed no association with prognosis. Conclusion: Oxidative DNA damage and DNA repair enzymes may be closely related to ICC progression.
AB - Background/Aim: The effects of oxidative stress on various carcinomas were reported in previous studies, but those in intrahepatic cholangiocarcinoma (ICC) have not been fully elucidated. The purpose of this study was, thus, to reveal the effects of oxidative DNA damage and repair enzymes on ICC. Materials and Methods: The levels of 8-hydroxydeoxyguanosine (8-OHdG) and 8-OHdG DNA glycosylase (OGG1) were immunohistochemically evaluated in specimens resected from 63 patients with ICC. Results: Low OGG1 expression was related to tumour depth T4 (p=0.04), venous invasion (p=0.0005), lymphatic vessel invasion (p=0.03), and perineural invasion (p=0.03). Compared to the high-OGG1-expression group, patients with low OGG1 expression had a significantly poorer prognosis (overall survival: p=0.04, recurrence-free survival: p=0.02). Unlike for OGG1, the expression levels of 8-OHdG showed no association with prognosis. Conclusion: Oxidative DNA damage and DNA repair enzymes may be closely related to ICC progression.
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U2 - 10.21873/anticanres.13465
DO - 10.21873/anticanres.13465
M3 - Article
C2 - 31177174
AN - SCOPUS:85067541583
SN - 0250-7005
VL - 39
SP - 3241
EP - 3248
JO - Anticancer research
JF - Anticancer research
IS - 6
ER -
