TY - JOUR
T1 - The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion
AU - Itoigawa, Yoshiaki
AU - Suzuki, Osamu
AU - Sano, Hirotaka
AU - Anada, Takahisa
AU - Handa, Takuto
AU - Hatta, Taku
AU - Kuwahara, Yoshiyuki
AU - Takahashi, Atsushi
AU - Ezoe, Yushi
AU - Kaneko, Kazuo
AU - Itoi, Eiji
N1 - Publisher Copyright:
© 2015 Journal of Shoulder and Elbow Surgery Board of Trustees.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.
AB - Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.
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U2 - 10.1016/j.jse.2015.01.011
DO - 10.1016/j.jse.2015.01.011
M3 - Article
C2 - 25825137
AN - SCOPUS:84930537513
SN - 1058-2746
VL - 24
SP - e175-e184
JO - Journal of Shoulder and Elbow Surgery
JF - Journal of Shoulder and Elbow Surgery
IS - 7
ER -