The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α

Hitoshi Nishimura, Masashi Emoto, Kenji Hiromatsu, Shunsuke Yamamoto, Keiko Matsuura, Hiroshi Gomi, Toshio Ikeda, Shigeyoshi Itohara, Yasunobu Yoshikai

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81 Citations (Scopus)

Abstract

The secretion of tumor necrosis factor (TNF)‐α from macrophages is regulated by both priming and triggering signals. We found that macrophages from mice lacking γδ T cells [T cell receptor (TCR) δ−/‐ mice], which lack the gene encoding the δ chain, produced only small amounts of TNF‐α in response to lipopolysaccharide (LPS) and showed a reduced level of expression of CD14. Pre‐incubation of macrophages from TCR δ‐/‐ mice with γδ T cells from their TCR δ+/‐ littermates restored their capacity to produce TNF‐α in response to LPS. The priming activity of γδ T cells was in part inhibited by neutralizing anti‐interferon (IFN)‐γ monoclonal antibodies. Collectively, these results suggest that γδ T cells play a role in priming macrophages to a steady state of activation via IFN‐γ secretion, which allows them to produce TNF‐α when exposed to LPS.

Original languageEnglish
Pages (from-to)1465-1468
Number of pages4
JournalEuropean Journal of Immunology
Volume25
Issue number5
DOIs
Publication statusPublished - May 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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