The replication machinery of LUCA: Common origin of DNA replication and transcription

Eugene V. Koonin; Mart Krupovic; Sonoko Ishino; Yoshizumi Ishino

doi:10.1186/s12915-020-00800-9

The replication machinery of LUCA: Common origin of DNA replication and transcription

Eugene V. Koonin, Mart Krupovic, Sonoko Ishino, Yoshizumi Ishino

Molecular Biosciences

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36 Citations (Scopus)

Abstract

Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.

Original language	English
Article number	61
Journal	BMC biology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12915-020-00800-9
Publication status	Published - Jun 9 2020

All Science Journal Classification (ASJC) codes

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Plant Science
Developmental Biology
Cell Biology

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AU - Ishino, Yoshizumi

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The replication machinery of LUCA: Common origin of DNA replication and transcription

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