The renin-angiotensin system in acute respiratory distress syndrome

Yumiko Imai, Keiji Kuba, Josef M. Penninger

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin-angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalDrug Discovery Today: Disease Mechanisms
Issue number2
Publication statusPublished - 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery


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