The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato; Shingo Kobayashi; Miho Kusakari; Shogo Watahiki; Masahiko Oikawa; Takashi Hoshiba; Masaru Tanaka

doi:10.1002/mabi.201500078

The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

Department of Soft Materials Chemistry

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

Original language	English
Pages (from-to)	1296-1303
Number of pages	8
Journal	Macromolecular Bioscience
Volume	15
Issue number	9
DOIs	https://doi.org/10.1002/mabi.201500078
Publication status	Published - Sept 1 2015

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/mabi.201500078

Cite this

@article{99b98369d2464c03a272f383a2b8be09,

title = "The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues",

abstract = "Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.",

author = "Kazuhiro Sato and Shingo Kobayashi and Miho Kusakari and Shogo Watahiki and Masahiko Oikawa and Takashi Hoshiba and Masaru Tanaka",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = sep,

day = "1",

doi = "10.1002/mabi.201500078",

language = "English",

volume = "15",

pages = "1296--1303",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "9",

}

TY - JOUR

T1 - The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

AU - Sato, Kazuhiro

AU - Kobayashi, Shingo

AU - Kusakari, Miho

AU - Watahiki, Shogo

AU - Oikawa, Masahiko

AU - Hoshiba, Takashi

AU - Tanaka, Masaru

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

AB - Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

UR - http://www.scopus.com/inward/record.url?scp=84940796696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940796696&partnerID=8YFLogxK

U2 - 10.1002/mabi.201500078

DO - 10.1002/mabi.201500078

M3 - Article

C2 - 26017931

AN - SCOPUS:84940796696

SN - 1616-5187

VL - 15

SP - 1296

EP - 1303

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 9

ER -

The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this