TY - JOUR
T1 - The regulatory role of Vα14 NKT cells in innate and acquired immune response
AU - Taniguchi, Masaru
AU - Harada, Michishige
AU - Kojo, Satoshi
AU - Nakayama, Toshinori
AU - Wakao, Hiroshi
PY - 2003
Y1 - 2003
N2 - A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 antigen receptor that is essential for their development. Successful identification of a specific ligand, α-galactosylceramide(α-GalCer), and the establishment of gene-manipulated mice with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of Vα14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
AB - A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 antigen receptor that is essential for their development. Successful identification of a specific ligand, α-galactosylceramide(α-GalCer), and the establishment of gene-manipulated mice with selective loss of Vα14 NKT cells helped elucidate the remarkable functional diversity of Vα14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
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U2 - 10.1146/annurev.immunol.21.120601.141057
DO - 10.1146/annurev.immunol.21.120601.141057
M3 - Review article
C2 - 12543936
AN - SCOPUS:0038228956
SN - 0732-0582
VL - 21
SP - 483
EP - 513
JO - Annual Review of Immunology
JF - Annual Review of Immunology
ER -