The pleiotropic functions of the Y-box-binding protein, YB-1

Kimitoshi Kohno, Hiroto Izumi, Takeshi Uchiumi, Megumi Ashizuka, Michihiko Kuwano

Research output: Contribution to journalReview articlepeer-review

445 Citations (Scopus)


The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.

Original languageEnglish
Pages (from-to)691-698
Number of pages8
Issue number7
Publication statusPublished - Jul 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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