The NRSE smRNA specifies the fate of adult hippocampal neural stem cells.

Tomoko Kuwabara, Jenny Hsieh, Kinichi Nakashima, Masaki Warashina, Kazunari Taira, Fred H. Gage

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Recently we found that the nuclear localized small modulatory double-stranded (ds) RNA (smRNA) coding NRSE sequences triggered activation of transcription of NRSE genes in adult hippocampal neural stem cells. NRSE smRNA, which are non-coding dsRNAs about 20 bp in length, reside in the nucleus and play a critical role in mediating neuronal differentiation. These smRNAs carry the sequence of NRSE/RE1, which is recognized by the NRSF/REST transcription factor. The NRSE sequences are embedded widely in the genomic region, typically in promoters of neuron-specific genes. The mechanism of action appears to be mediated through a specific interaction between dsRNA and DNA/protein interaction, rather than through siRNA or miRNA. The discovery of smRNAs extends the important contribution of non-coding RNAs as key regulators of cell fate choice for adult neurogenesis.

Original languageEnglish
Pages (from-to)87-88
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
Publication statusPublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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