TY - JOUR
T1 - The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients
AU - Marui, Tomoyasu
AU - Torii, Youta
AU - Iritani, Shuji
AU - Sekiguchi, Hirotaka
AU - Habuchi, Chikako
AU - Fujishiro, Hiroshige
AU - Oshima, Kenichi
AU - Niizato, Kazuhiro
AU - Hayashida, Shotaro
AU - Masaki, Katsuhisa
AU - Kira, Junichi
AU - Ozaki, Norio
N1 - Publisher Copyright:
© Scandinavian College of Neuropsychopharmacology 2018.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objective Recent studies based on the neuroimaging analysis, genomic analysis and transcriptome analysis of the postmortem brain suggest that the pathogenesis of schizophrenia is related to myelin-oligodendrocyte abnormalities. However, no serious neuropathological investigation of this protein in the schizophrenic brain has yet been performed. In this study, to confirm the change in neuropathological findings due to the pathogenesis of this disease, we observed the expression of myelin-oligodendrocyte directly in the brain tissue of schizophrenia patients.Methods Myelin oligodendrocyte glycoprotein (MOG) was evaluated in the cortex of the superior temporal gyrus (STG) and the hippocampus in 10 schizophrenic and nine age- And sex-matched normal control postmortem brains.Results The expression of MOG was significantly lower in the middle layer of the neocortex of the STG and stratum lucidum of CA3 in the hippocampus in the long-term schizophrenic brains (patients with ≥30 years of illness duration) than in the age-matched controls. Furthermore, the thickness of MOG-positive fibre-like structures was significantly lower in both regions of the long-term schizophrenic brains than in the age-matched controls.Conclusion These findings suggest that a long duration of illness has a marked effect on the expression of MOG in these regions, and that myelin-oligodendrocyte abnormalities in these regions may be related to the progressive pathophysiology of schizophrenia.
AB - Objective Recent studies based on the neuroimaging analysis, genomic analysis and transcriptome analysis of the postmortem brain suggest that the pathogenesis of schizophrenia is related to myelin-oligodendrocyte abnormalities. However, no serious neuropathological investigation of this protein in the schizophrenic brain has yet been performed. In this study, to confirm the change in neuropathological findings due to the pathogenesis of this disease, we observed the expression of myelin-oligodendrocyte directly in the brain tissue of schizophrenia patients.Methods Myelin oligodendrocyte glycoprotein (MOG) was evaluated in the cortex of the superior temporal gyrus (STG) and the hippocampus in 10 schizophrenic and nine age- And sex-matched normal control postmortem brains.Results The expression of MOG was significantly lower in the middle layer of the neocortex of the STG and stratum lucidum of CA3 in the hippocampus in the long-term schizophrenic brains (patients with ≥30 years of illness duration) than in the age-matched controls. Furthermore, the thickness of MOG-positive fibre-like structures was significantly lower in both regions of the long-term schizophrenic brains than in the age-matched controls.Conclusion These findings suggest that a long duration of illness has a marked effect on the expression of MOG in these regions, and that myelin-oligodendrocyte abnormalities in these regions may be related to the progressive pathophysiology of schizophrenia.
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U2 - 10.1017/neu.2018.6
DO - 10.1017/neu.2018.6
M3 - Article
C2 - 29564992
AN - SCOPUS:85044282298
SN - 0924-2708
VL - 30
SP - 232
EP - 240
JO - Acta Neuropsychiatrica
JF - Acta Neuropsychiatrica
IS - 4
ER -
