TY - JOUR
T1 - The molecular pathogenesis of collagen-induced arthritis in mice - A model for rheumatoid arthritis
AU - Holmdahl, Rikard
AU - Bockermann, Robert
AU - Bäcklund, Johan
AU - Yamada, Hisakata
N1 - Funding Information:
We thank the King Gustaf V:s 80-year foundation, the Kock and Österlund Foundations, the Swedish Association against Rheumatism, the Swedish Medical Research Council and The Swedish Foundation for Strategic Research for supporting our work.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/2
Y1 - 2002/2
N2 - The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFα neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis.
AB - The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFα neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis.
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U2 - 10.1016/S0047-6374(01)00371-2
DO - 10.1016/S0047-6374(01)00371-2
M3 - Review article
C2 - 12039453
AN - SCOPUS:0036484325
SN - 1568-1637
VL - 1
SP - 135
EP - 147
JO - Ageing Research Reviews
JF - Ageing Research Reviews
IS - 1
ER -