TY - JOUR
T1 - The loss of 8p23.3 is a novel marker for predicting progression and recurrence of bladder tumors without muscle invasion
AU - Eguchi, Satoshi
AU - Yamamoto, Yoshiaki
AU - Sakano, Shigeru
AU - Chochi, Yasuyo
AU - Nakao, Motonao
AU - Kawauchi, Shigeto
AU - Furuya, Tomoko
AU - Oga, Atsunori
AU - Matsuyama, Hideyasu
AU - Sasaki, Kohsuke
PY - 2010/7
Y1 - 2010/7
N2 - There are few reliable markers to distinguish tumors with aggressive characteristics from others at the time of initial diagnosis in non-muscle-invasive bladder cancer. The purpose of this study was to identify a genomic marker that allows the prediction of prognosis for non-muscle-invasive bladder cancers. We screened the genome-wide copy number in 41 patients with non-muscle-invasive urothelial carcinoma of the bladder by array-based comparative genomic hybridization using arrays spotted with 4,030 bacterial artificial chromosome clones. A loss of 8p23.3 (clone 923) was correlated significantly with a higher histological grade (P = 0.0026) and advanced pathological stage (P = 0.0148). Both recurrence-free and progression-free survival rates were lower in patients with tumors without 8p23.3, compared with those with 8p23.3 (P = 0.0146 and 0.0473, respectively; log-rank test). These data suggest that the loss of 8p23.3 is a novel genomic marker allowing estimation of biological characteristics of non-muscle-invasive bladder cancer.
AB - There are few reliable markers to distinguish tumors with aggressive characteristics from others at the time of initial diagnosis in non-muscle-invasive bladder cancer. The purpose of this study was to identify a genomic marker that allows the prediction of prognosis for non-muscle-invasive bladder cancers. We screened the genome-wide copy number in 41 patients with non-muscle-invasive urothelial carcinoma of the bladder by array-based comparative genomic hybridization using arrays spotted with 4,030 bacterial artificial chromosome clones. A loss of 8p23.3 (clone 923) was correlated significantly with a higher histological grade (P = 0.0026) and advanced pathological stage (P = 0.0148). Both recurrence-free and progression-free survival rates were lower in patients with tumors without 8p23.3, compared with those with 8p23.3 (P = 0.0146 and 0.0473, respectively; log-rank test). These data suggest that the loss of 8p23.3 is a novel genomic marker allowing estimation of biological characteristics of non-muscle-invasive bladder cancer.
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U2 - 10.1016/j.cancergencyto.2010.03.007
DO - 10.1016/j.cancergencyto.2010.03.007
M3 - Article
C2 - 20513529
AN - SCOPUS:77953338808
SN - 0165-4608
VL - 200
SP - 16
EP - 22
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
