The life-extending effect of dietary restriction requires Foxo3 in mice

Isao Shimokawa; Toshimitsu Komatsu; Nobutaka Hayashi; Sang Eun Kim; Takuya Kawata; Seongjoon Park; Hiroko Hayashi; Haruyoshi Yamaza; Takuya Chiba; Ryoichi Mori

doi:10.1111/ACEL.12340

The life-extending effect of dietary restriction requires Foxo3 in mice

Isao Shimokawa, Toshimitsu Komatsu, Nobutaka Hayashi, Sang Eun Kim, Takuya Kawata, Seongjoon Park, Hiroko Hayashi, Haruyoshi Yamaza, Takuya Chiba, Ryoichi Mori

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (^+/–) and homozygous (^–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3^+/– or Foxo3^–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3^+/–, and Foxo3^–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3^+/– mice contrast with those in Foxo1^+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

Original language	English
Pages (from-to)	707-709
Number of pages	3
Journal	Aging cell
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/ACEL.12340
Publication status	Published - Aug 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Ageing
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/ACEL.12340

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title = "The life-extending effect of dietary restriction requires Foxo3 in mice",

abstract = "Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (+/–) and homozygous (–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3+/– or Foxo3–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3+/–, and Foxo3–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3+/– mice contrast with those in Foxo1+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.",

author = "Isao Shimokawa and Toshimitsu Komatsu and Nobutaka Hayashi and Kim, {Sang Eun} and Takuya Kawata and Seongjoon Park and Hiroko Hayashi and Haruyoshi Yamaza and Takuya Chiba and Ryoichi Mori",

note = "Funding Information: This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) (15390128, 16790226, and 20790260) and the JSPS Asian CORE Program. Publisher Copyright: {\textcopyright} 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.",

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doi = "10.1111/ACEL.12340",

language = "English",

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AU - Shimokawa, Isao

AU - Komatsu, Toshimitsu

AU - Hayashi, Nobutaka

AU - Kim, Sang Eun

AU - Kawata, Takuya

AU - Park, Seongjoon

AU - Hayashi, Hiroko

AU - Yamaza, Haruyoshi

AU - Chiba, Takuya

AU - Mori, Ryoichi

N1 - Funding Information: This study was supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS) (15390128, 16790226, and 20790260) and the JSPS Asian CORE Program. Publisher Copyright: © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

PY - 2015/8

Y1 - 2015/8

N2 - Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (+/–) and homozygous (–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3+/– or Foxo3–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3+/–, and Foxo3–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3+/– mice contrast with those in Foxo1+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

AB - Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous (+/–) and homozygous (–/–) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3+/– or Foxo3–/– mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3+/–, and Foxo3–/– mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3+/– mice contrast with those in Foxo1+/– mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.

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The life-extending effect of dietary restriction requires Foxo3 in mice

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