The interaction of sulfonated sugars with amyloid peptide of Aβ(1-42) and PrP(106-126)

Kikuko Yasuda, Mihoko Koike, Yoshiko Miura, Yoshihiro Nishida, Kazukiyo Kobayashi

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)


Biological active saccharide of proteoglycans and gangliosides has been reported to accelate the amyloid formation of Alzheimer peptide. Those reports indicated the strong interaction with Aβ.We have reported the synthesis and biological activity of sulfonated sugars for a sialic acid mimic.Here,we investigate the interaction between sulfonated GIcNAc and Aβ. The aggregation of Aβ with heparin and pNP 6-sulfo-GIcNAc was estimated by fluorescence of thioflavin T,CD spectra and TEM observations. Though heparin induced the aggregation and β-sheet conformation. pNP 6-sulfo-GIcNAc inhibited them.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sept 20 2005Sept 22 2005


Other54th SPSJ Symposium on Macromolecules

All Science Journal Classification (ASJC) codes

  • General Engineering


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