TY - JOUR
T1 - The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells
AU - Arung, Enos Tangke
AU - Furuta, Shoko
AU - Sugamoto, Kazuhiro
AU - Shimizu, Kuniyoshi
AU - Ishikawa, Hiroya
AU - Matsushita, Yoh Ichi
AU - Kondo, Ryuichiro
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2012/8
Y1 - 2012/8
N2 - In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
AB - In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
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U2 - 10.1177/1934578x1200700812
DO - 10.1177/1934578x1200700812
M3 - Article
C2 - 22978217
AN - SCOPUS:84865281313
SN - 1934-578X
VL - 7
SP - 1007
EP - 1010
JO - Natural product communications
JF - Natural product communications
IS - 8
ER -