The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati; Taslim Ersam; Kuniyoshi Shimizu

doi:10.1016/j.phymed.2014.11.001

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati, Taslim Ersam, Kuniyoshi Shimizu

Sustainable Bioresources Science

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC₅₀ value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC₅₀ of 3.48 μM.

Original language	English
Pages (from-to)	49-51
Number of pages	3
Journal	Phytomedicine
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.phymed.2014.11.001
Publication status	Published - Mar 2015

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1016/j.phymed.2014.11.001

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abstract = "We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.",

author = "Sri Fatmawati and Taslim Ersam and Kuniyoshi Shimizu",

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AU - Shimizu, Kuniyoshi

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The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Abstract

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