TY - JOUR
T1 - The Influence of Clinical T Factor on Predicting Pathologic N Factor in Resected Lung Cancer
AU - Shimamatsu, Shinichiro
AU - Takenoyama, Mitsuhiro
AU - Shimokawa, Mototsugu
AU - Takada, Kazuki
AU - Edagawa, Makoto
AU - Toyozawa, Ryo
AU - Nosaki, Kaname
AU - Oba, Taro
AU - Tagawa, Tetsuzo
AU - Yamaguchi, Masafumi
AU - Taguchi, Kenichi
AU - Seto, Takashi
N1 - Publisher Copyright:
© 2019 The Society of Thoracic Surgeons
PY - 2019/10
Y1 - 2019/10
N2 - Background: We investigated the utility of the clinical T factor of the 8th edition of the TNM classification, which newly defines the consolidation size of the tumor, as a valuable predictor of pathologic lymph node metastasis (pN+) and the prognosis. Methods: We retrospectively reviewed 825 patients with surgically resected cN0 M0 non-small cell lung cancer of any T stage, focusing on the tumor's total size (7th edition) and consolidation size (8th edition) and examined pN+ and the prognosis. Results: No pN+ cases in the 7th or 8th edition groups had a tumor size of less than 1 cm, and in those sized 1 to 3 cm, the frequency of pN+ in the 7th and 8th edition groups was 10.3% and 13.4%, respectively. The frequency of pN+ in tumors without ground glass opacity (GGO−) was 5.5-times higher than that of tumors with GGO (GGO+). The frequency of pN+ in the GGO+ 8th edition group was twice that in the GGO+ 7th edition group. The frequency of pN+ in the GGO− 7th edition group was 4-times higher than that of the GGO+ 7th edition group. A multivariate analysis revealed that total size exceeding 2 cm, consolidation size exceeding 2 cm, and GGO− were significant predictors of a pN+ status, indicating that a consolidation size of more than 2 cm was a stronger predictor than a total size of more than 2 cm. Conclusions: A consolidation size of more than 2 cm and GGO− were predictors of pN+, and the clinical T factor of the 8th Edition was a stronger predictor of the pN+ status than that of the 7th edition.
AB - Background: We investigated the utility of the clinical T factor of the 8th edition of the TNM classification, which newly defines the consolidation size of the tumor, as a valuable predictor of pathologic lymph node metastasis (pN+) and the prognosis. Methods: We retrospectively reviewed 825 patients with surgically resected cN0 M0 non-small cell lung cancer of any T stage, focusing on the tumor's total size (7th edition) and consolidation size (8th edition) and examined pN+ and the prognosis. Results: No pN+ cases in the 7th or 8th edition groups had a tumor size of less than 1 cm, and in those sized 1 to 3 cm, the frequency of pN+ in the 7th and 8th edition groups was 10.3% and 13.4%, respectively. The frequency of pN+ in tumors without ground glass opacity (GGO−) was 5.5-times higher than that of tumors with GGO (GGO+). The frequency of pN+ in the GGO+ 8th edition group was twice that in the GGO+ 7th edition group. The frequency of pN+ in the GGO− 7th edition group was 4-times higher than that of the GGO+ 7th edition group. A multivariate analysis revealed that total size exceeding 2 cm, consolidation size exceeding 2 cm, and GGO− were significant predictors of a pN+ status, indicating that a consolidation size of more than 2 cm was a stronger predictor than a total size of more than 2 cm. Conclusions: A consolidation size of more than 2 cm and GGO− were predictors of pN+, and the clinical T factor of the 8th Edition was a stronger predictor of the pN+ status than that of the 7th edition.
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U2 - 10.1016/j.athoracsur.2019.04.026
DO - 10.1016/j.athoracsur.2019.04.026
M3 - Article
C2 - 31103386
AN - SCOPUS:85071440198
SN - 0003-4975
VL - 108
SP - 1080
EP - 1086
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 4
ER -
