TY - JOUR
T1 - The impact of surgical treatment and poor prognostic factors for patients with intrahepatic cholangiocarcinoma
T2 - Retrospective analysis of 60 patients
AU - Yamashita, Yo Ichi
AU - Taketomi, Akinobu
AU - Morita, Kazutoyo
AU - Fukuhara, Takasuke
AU - Ueda, Shigeru
AU - Sanefuji, Kensaku
AU - Iguchi, Tomohiro
AU - Kayashima, Hiroto
AU - Sugimachi, Keishi
AU - Maehara, Yoshihiko
PY - 2008/7
Y1 - 2008/7
N2 - Background: Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct. Hepatectomy with extensive lymph node dissection is the standard treatment for ICC. Patients and Methods: Sixty patients with ICC who underwent hepatectomy in our institution between 1986 and 2005 were investigated to determine prognostic factors and to evaluate the impact of surgical treatment for ICC using univariate and multivariate analyses. Results: The overall survival rate of the RO resection group (n=43) was significantly higher than that of the R1/2 group (n=17). However, in patients with lymph node metastasis (n=24), R0 resection had no survival impact. According to multivariate analysis, the independent factors of poor prognosis were: the presence of lymph node metastasis, lymphatic invasion, poor differentiation and R1/2 resection. Conclusion: R0 resection can provide prolonged survival for patients with ICC. Patients with lymph node metastasis, lymphatic invasion, or poorly differentiated ICC have poor prognosis after operation and additional treatment, such as adjuvant chemotherapy, is recommended.
AB - Background: Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma of the liver arising from the intrahepatic bile duct. Hepatectomy with extensive lymph node dissection is the standard treatment for ICC. Patients and Methods: Sixty patients with ICC who underwent hepatectomy in our institution between 1986 and 2005 were investigated to determine prognostic factors and to evaluate the impact of surgical treatment for ICC using univariate and multivariate analyses. Results: The overall survival rate of the RO resection group (n=43) was significantly higher than that of the R1/2 group (n=17). However, in patients with lymph node metastasis (n=24), R0 resection had no survival impact. According to multivariate analysis, the independent factors of poor prognosis were: the presence of lymph node metastasis, lymphatic invasion, poor differentiation and R1/2 resection. Conclusion: R0 resection can provide prolonged survival for patients with ICC. Patients with lymph node metastasis, lymphatic invasion, or poorly differentiated ICC have poor prognosis after operation and additional treatment, such as adjuvant chemotherapy, is recommended.
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M3 - Article
C2 - 18751418
AN - SCOPUS:48849112571
SN - 0250-7005
VL - 28
SP - 2353
EP - 2359
JO - Anticancer research
JF - Anticancer research
IS - 4 C
ER -
