The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene

Gouji Toyokawa; Mitsuhiro Takenoyama; Kenichi Taguchi; Katsumi Arakaki; Eiko Inamasu; Ryo Toyozawa; Miyako Kojo; Yoshimasa Shiraishi; Yosuke Morodomi; Tomoyoshi Takenaka; Fumihiko Hirai; Masafumi Yamaguchi; Takashi Seto; Alvaro Leone; Paolo Graziano; Yukito Ichinose

doi:10.1016/j.lungcan.2013.06.013

The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene

Gouji Toyokawa, Mitsuhiro Takenoyama, Kenichi Taguchi, Katsumi Arakaki, Eiko Inamasu, Ryo Toyozawa, Miyako Kojo, Yoshimasa Shiraishi, Yosuke Morodomi, Tomoyoshi Takenaka, Fumihiko Hirai, Masafumi Yamaguchi, Takashi Seto, Alvaro Leone, Paolo Graziano, Yukito Ichinose

Cancer Center

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Mutations of the epidermal growth factor receptor ( EGFR) gene play a critical role in carcinogenesis of lung cancer, particularly adenocarcinoma. However, to the best of our knowledge, no mutations of the EGFR in patients with lung carcinosarcoma have been identified. We herein report the case of a 61-year-old female referred for a detailed examination of a left pulmonary mass shadow. Although bronchoscopy was performed, it failed to lead to a diagnosis, and video-assisted thoracoscopic surgery was therefore carried out to diagnose the tumor. The pathology revealed biphasic features consisting of both adenocarcinoma and chondrosarcoma. Intriguingly, both the adenocarcinoma and chondrosarcoma components were proven to harbor an exon19 deletion in the EGFR gene. Although carcinosarcoma is a rare malignancy of the lungs, genetic analyses of oncogenic drivers, such as the EGFR gene, should be conducted.

Original language	English
Pages (from-to)	491-494
Number of pages	4
Journal	Lung Cancer
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2013.06.013
Publication status	Published - Sept 2013

All Science Journal Classification (ASJC) codes

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.lungcan.2013.06.013

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Toyokawa, G., Takenoyama, M., Taguchi, K., Arakaki, K., Inamasu, E., Toyozawa, R., Kojo, M., Shiraishi, Y., Morodomi, Y., Takenaka, T., Hirai, F., Yamaguchi, M., Seto, T., Leone, A., Graziano, P., & Ichinose, Y. (2013). The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene. Lung Cancer, 81(3), 491-494. https://doi.org/10.1016/j.lungcan.2013.06.013

Toyokawa, G, Takenoyama, M, Taguchi, K, Arakaki, K, Inamasu, E, Toyozawa, R, Kojo, M, Shiraishi, Y , Morodomi, Y , Takenaka, T, Hirai, F, Yamaguchi, M, Seto, T, Leone, A, Graziano, P & Ichinose, Y 2013, 'The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene', Lung Cancer, vol. 81, no. 3, pp. 491-494. https://doi.org/10.1016/j.lungcan.2013.06.013

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title = "The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene",

abstract = "Mutations of the epidermal growth factor receptor ( EGFR) gene play a critical role in carcinogenesis of lung cancer, particularly adenocarcinoma. However, to the best of our knowledge, no mutations of the EGFR in patients with lung carcinosarcoma have been identified. We herein report the case of a 61-year-old female referred for a detailed examination of a left pulmonary mass shadow. Although bronchoscopy was performed, it failed to lead to a diagnosis, and video-assisted thoracoscopic surgery was therefore carried out to diagnose the tumor. The pathology revealed biphasic features consisting of both adenocarcinoma and chondrosarcoma. Intriguingly, both the adenocarcinoma and chondrosarcoma components were proven to harbor an exon19 deletion in the EGFR gene. Although carcinosarcoma is a rare malignancy of the lungs, genetic analyses of oncogenic drivers, such as the EGFR gene, should be conducted.",

author = "Gouji Toyokawa and Mitsuhiro Takenoyama and Kenichi Taguchi and Katsumi Arakaki and Eiko Inamasu and Ryo Toyozawa and Miyako Kojo and Yoshimasa Shiraishi and Yosuke Morodomi and Tomoyoshi Takenaka and Fumihiko Hirai and Masafumi Yamaguchi and Takashi Seto and Alvaro Leone and Paolo Graziano and Yukito Ichinose",

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AU - Toyokawa, Gouji

AU - Takenoyama, Mitsuhiro

AU - Taguchi, Kenichi

AU - Arakaki, Katsumi

AU - Inamasu, Eiko

AU - Toyozawa, Ryo

AU - Kojo, Miyako

AU - Shiraishi, Yoshimasa

AU - Morodomi, Yosuke

AU - Takenaka, Tomoyoshi

AU - Hirai, Fumihiko

AU - Yamaguchi, Masafumi

AU - Seto, Takashi

AU - Leone, Alvaro

AU - Graziano, Paolo

AU - Ichinose, Yukito

PY - 2013/9

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N2 - Mutations of the epidermal growth factor receptor ( EGFR) gene play a critical role in carcinogenesis of lung cancer, particularly adenocarcinoma. However, to the best of our knowledge, no mutations of the EGFR in patients with lung carcinosarcoma have been identified. We herein report the case of a 61-year-old female referred for a detailed examination of a left pulmonary mass shadow. Although bronchoscopy was performed, it failed to lead to a diagnosis, and video-assisted thoracoscopic surgery was therefore carried out to diagnose the tumor. The pathology revealed biphasic features consisting of both adenocarcinoma and chondrosarcoma. Intriguingly, both the adenocarcinoma and chondrosarcoma components were proven to harbor an exon19 deletion in the EGFR gene. Although carcinosarcoma is a rare malignancy of the lungs, genetic analyses of oncogenic drivers, such as the EGFR gene, should be conducted.

AB - Mutations of the epidermal growth factor receptor ( EGFR) gene play a critical role in carcinogenesis of lung cancer, particularly adenocarcinoma. However, to the best of our knowledge, no mutations of the EGFR in patients with lung carcinosarcoma have been identified. We herein report the case of a 61-year-old female referred for a detailed examination of a left pulmonary mass shadow. Although bronchoscopy was performed, it failed to lead to a diagnosis, and video-assisted thoracoscopic surgery was therefore carried out to diagnose the tumor. The pathology revealed biphasic features consisting of both adenocarcinoma and chondrosarcoma. Intriguingly, both the adenocarcinoma and chondrosarcoma components were proven to harbor an exon19 deletion in the EGFR gene. Although carcinosarcoma is a rare malignancy of the lungs, genetic analyses of oncogenic drivers, such as the EGFR gene, should be conducted.

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The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene

Abstract

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UN SDGs

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