TY - JOUR
T1 - The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
AU - Ishii, Hideshi
AU - Baffa, Raffaele
AU - Numata, Shin Ichiro
AU - Murakumo, Yoshiki
AU - Rattan, Shashi
AU - Inoue, Hiroshi
AU - Mori, Masaki
AU - Fidanza, Vincenzo
AU - Alder, Hansjuerg
AU - Croce, Carlo M.
PY - 1999/3/30
Y1 - 1999/3/30
N2 - Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
AB - Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
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U2 - 10.1073/pnas.96.7.3928
DO - 10.1073/pnas.96.7.3928
M3 - Article
C2 - 10097140
AN - SCOPUS:13044313477
SN - 0027-8424
VL - 96
SP - 3928
EP - 3933
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -
