The efficient entry into the tricyclic core of halichlorine

Mitsuru Shindo, Yu Ichi Fukuda, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


An efficient and diastereoselective synthesis of the tricyclic core structure 3 found in the marine alkaloid halichlorine 1 has been accomplished starting from Grigg's tricyclic isoxazolidine 5, which was prepared by the tandem intramolecular Michael addition-[3+2] cycloaddition of the corresponding oxime of 4. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)929-932
Number of pages4
JournalTetrahedron Letters
Issue number6
Publication statusPublished - Feb 5 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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