An efficient and diastereoselective synthesis of the tricyclic core structure 3 found in the marine alkaloid halichlorine 1 has been accomplished starting from Grigg's tricyclic isoxazolidine 5, which was prepared by the tandem intramolecular Michael addition-[3+2] cycloaddition of the corresponding oxime of 4. (C) 2000 Elsevier Science Ltd.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry