The effects of various metallic surfaces on cellular and bacterial adhesion

Masaya Shimabukuro, Haruka Ito, Yusuke Tsutsumi, Kosuke Nozaki, Peng Chen, Risa Yamada, Maki Ashida, Akiko Nagai, Takao Hanawa

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The effects of Ti, Nb, Ta, Zr, and Ag on cellular and bacterial adhesion were investigated in this study. Moreover, the relationships between surface compositions, metal ion release behaviors, and biological responses were examined. As a result, MC3T3-E1 cells and S. aureus were able to better attach to Ti and Zr rather than the Nb and Ta specimens. For the Ag specimen, the amount of Ag ions released into Hanks’ solution was the largest among all the specimens. Cellular and bacterial adhesion onto the Ag specimen was inhibited compared with the other specimens, because of Ag ion release. Alternatively, Nb and Ta specimens exhibited specific biological responses. Cellular adhesion on Nb and Ta specimens was similar to that on Ti, while bacterial adhesion on Nb and Ta specimens was inhibited compared with that on Ti. This study proved that Nb and Ta inhibited bacterial adhesion and exhibited no harmful effects on cellular adhesion. In addition, these results indicate that the passive layer on Nb and Ta plays a key role in the inhibition of bacterial adhesion.

Original languageEnglish
Article number1145
Issue number11
Publication statusPublished - Nov 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Metals and Alloys


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