The effects of polaprezinc on radiation-induced taste alterations

K. Nakamura, N. Shikama, O. Togao, S. Sasaki, A. Shinoda, N. Kunitake, M. Kimura, T. Watanabe, T. Sasaki, H. Terashima, K. Masuda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The effects of polaprezinc (an insoluble zinc complex of L-carnosine) on taste abnormalities were investigated in 22 patients receiving radiation therapy to head and neck malignancies. The total doses to the tongue were 25.5-46.0 Gy (mean, 37.9 Gy). All patients received 75 mg of polaprezinc two times a day with an interval of 0-1,561 days (mean, 305.3 days) after the completion of radiation therapy. The duration of the drug administration was 25-353 days (mean, 96.9 days). Twenty patients (90.9%) were aware of an improvement of a partial or complete loss of taste. Polaprezinc is effective in improving loss of taste after radiation therapy.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalJournal of JASTRO
Issue number2
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Oncology


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