The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells

Jie Liu; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1016/j.fitote.2010.06.029

The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells

Jie Liu, Kuniyoshi Shimizu, Ryuichiro Kondo

Sustainable Bioresources Science

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18 Citations (Scopus)

Abstract

The effects of ganoderma alcohols isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) on the androgen receptor binding and the growth of LNCaP cells have been investigated. Less than two hydroxyl groups in 17β-side chain are needed for binding to androgen receptor. In the case of the ganoderma alcohols with the same number of hydroxyl groups in 17β-side chain, the one which has C-3 carbonyl group showed better binding activity to androgen receptor than that which has C-3 hydroxyl group. The unsaturation in 17β-side chain is needed for the inhibition of the cell proliferation of androgen-induced LNCaP cells growth.

Original language	English
Pages (from-to)	1067-1072
Number of pages	6
Journal	Fitoterapia
Volume	81
Issue number	8
DOIs	https://doi.org/10.1016/j.fitote.2010.06.029
Publication status	Published - Dec 2010

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1016/j.fitote.2010.06.029

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abstract = "The effects of ganoderma alcohols isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) on the androgen receptor binding and the growth of LNCaP cells have been investigated. Less than two hydroxyl groups in 17β-side chain are needed for binding to androgen receptor. In the case of the ganoderma alcohols with the same number of hydroxyl groups in 17β-side chain, the one which has C-3 carbonyl group showed better binding activity to androgen receptor than that which has C-3 hydroxyl group. The unsaturation in 17β-side chain is needed for the inhibition of the cell proliferation of androgen-induced LNCaP cells growth.",

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The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells

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