The Effect of Recombinant Human Erythropoietin on Pre and Postoperative Anemia in Patients Undergoing General Surgery —Multicentral Trial—

Keisuke Yoshida, Terukazu Muto, Shozo Mori, Tetsuro Nishihira, Katsuji Okui, Tsuguhiro Tashiro, Yasuhiko Morioka, Tetsuichiro Muto, Kimitaka Suzuki, Osahiko Abe, Masakazu Ueda, Masahiko Tsurumaru, Harushi Udagawa, Takesada Mori, Junichi Kanbayashi, Keizo Sugimachi, Makoto Hashizume, Hisaaki Shimazu, Sonshin Takao

Research output: Contribution to journalArticlepeer-review


The usefulness of recombinant human erythropoietin (r-HuEPO) to eliminate the need for perioperative blood transfusion was investigated in patients who mostly underwent digestive tract surgery. A dose of 200 IU of r-HuEPO per kg was given concomitantly with iron (40 mg) for 7 days before and for 14 days after surgery. Hemoglobin, hematocrit and red blood cell levels significantly increased following preoperative administration of r-HuEPO for 7 days. However, the increase in hemoglobin was only 0.3 g/dl on average. Therefore, further studies appear necessary to find a more effective method of administration, i.e. a more appropriate dosage and administration period. Postoperative anemia was improved from the 4th postoperative day (POD), a significantly better result than that seen in controls whose hematocrit continued to decrease up to the 10th POD. As side effects, a flu-like syndrome, hepatic function disorder, fever and rash were seen in one patient each. Two patients had abnormal laboratory findings. Of these, one showed a rise in GOT, GPT and Al-p and the other showed a rise in LDH. These side effects and abnormal laboratory findings were, however, not severe. Fever and the rise in LDH were judged to be related to r-HuEPO therapy. These results suggest that perioperative administration of r-HuEPO is safe and useful for eliminate, or reduce the volume of blood transfusion in general surgery.

Original languageEnglish
Pages (from-to)92-101
Number of pages10
Journalthe japanese journal of gastroenterological surgery
Issue number1
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology


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