The effect of probiotics on gastric mucosal permeability in humans administered with aspirin

Fumiaki Akama, Ryo Nishino, Seiya Makino, Kiyoshi Kobayashi, Kazufumi Kamikaseda, Jun Nagano, Yasuhiro Koga

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)


    Objective. To examine whether a probiotic strain, Lactobacillus gasseri OLL2716 (LG21), can protect the gastric mucosal integrity from aspirin using urinary sucrose excretion (USE) test. Materials and methods. In the study using high-dose aspirin, the USE tests were carried out in 29 volunteers before and after LG21 treatment for 4 weeks. In the study using patients undergoing low-dose aspirin therapy, USE tests were performed in 37 subjects who took LG21 for 16 weeks. Stool occult blood was examined by the guaiac method. Results. In the former study, the elevation in the USE value after aspirin loading significantly decreased after LG21 treatment (Median ± SD; 0.244 ± 0.237 vs. 0.208 ± 0.112%, p = 0.018). In the latter study, the USE value significantly decreased in the period with LG21 treatment (p = 0.033), while no significant difference was found in the period without LG21 (p = 0.113). The number of positive occult blood tests decreased during LG21 treatment. Conclusions. The regular ingestion of LG21 may protect the integrity of the gastric mucosal permeability against aspirin.

    Original languageEnglish
    Pages (from-to)831-836
    Number of pages6
    JournalScandinavian Journal of Gastroenterology
    Issue number7-8
    Publication statusPublished - Jul 2011

    All Science Journal Classification (ASJC) codes

    • Gastroenterology


    Dive into the research topics of 'The effect of probiotics on gastric mucosal permeability in humans administered with aspirin'. Together they form a unique fingerprint.

    Cite this