The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

Tomohiro Masuzaki; Yasunori Ayukawa; Yasuko Moriyama; Yohei Jinno; Ikiru Atsuta; Yoichiro Ogino; Kiyoshi Koyano

doi:10.1016/j.biomaterials.2010.01.016

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

Tomohiro Masuzaki, Yasunori Ayukawa, Yasuko Moriyama, Yohei Jinno, Ikiru Atsuta, Yoichiro Ogino, Kiyoshi Koyano

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone.

Original language	English
Pages (from-to)	3327-3334
Number of pages	8
Journal	Biomaterials
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.biomaterials.2010.01.016
Publication status	Published - Apr 2010

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2010.01.016

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title = "The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia",

abstract = "The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone.",

author = "Tomohiro Masuzaki and Yasunori Ayukawa and Yasuko Moriyama and Yohei Jinno and Ikiru Atsuta and Yoichiro Ogino and Kiyoshi Koyano",

note = "Funding Information: This study was supported in part by KAKENHI (nos. 20390490 and 21390520 ) from the Japan Society for the Promotion of Science. Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",

year = "2010",

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doi = "10.1016/j.biomaterials.2010.01.016",

language = "English",

volume = "31",

pages = "3327--3334",

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AU - Masuzaki, Tomohiro

AU - Ayukawa, Yasunori

AU - Moriyama, Yasuko

AU - Jinno, Yohei

AU - Atsuta, Ikiru

AU - Ogino, Yoichiro

AU - Koyano, Kiyoshi

N1 - Funding Information: This study was supported in part by KAKENHI (nos. 20390490 and 21390520 ) from the Japan Society for the Promotion of Science. Copyright: Copyright 2010 Elsevier B.V., All rights reserved.

PY - 2010/4

Y1 - 2010/4

N2 - The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone.

AB - The aim of this study was to evaluate the effects of newly developed injectable poly (lactic-co-glycolic acid) (PLGA) microspheres containing fluvastatin on osteogenesis around titanium implants in the rat tibia. After confirmation of the sustained-release profile of fluvastatin from the microspheres by an in vitro assay, the microspheres were administered to the back skin of the rats by a single transdermal injection. At 2 and 4 weeks after the implant surgery, the fluvastatin groups showed enhanced new bone formation around the titanium implants without any influence on the serum biochemistry. In addition, the fluvastatin groups showed increased three-point bending strengths of their femurs. The results of this study indicate that a single remote injection of PLGA/fluvastatin microspheres safely and successfully stimulated bone formation around titanium implants and increased the mechanical properties of bone.

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The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia

Abstract

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