TY - JOUR
T1 - The Dual Nature of Microglia in Alzheimer’s Disease
T2 - A Microglia-Neuron Crosstalk Perspective
AU - Xie, Zhen
AU - Meng, Jie
AU - Wu, Zhou
AU - Nakanishi, Hiroshi
AU - Hayashi, Yoshinori
AU - Kong, Wei
AU - Lan, Fei
AU - Narengaowa,
AU - Yang, Qinghu
AU - Qing, Hong
AU - Ni, Junjun
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Beijing Natural Science Foundation (Grant No. 7212066), the National Natural Science Foundation of China (Grant No. 32070954), the PhD research startup foundation of Yan’an university (Grant No. YDBK2019-41), the Yan’an High-level Talent Project (Grant No. 203010108), and China Postdoctoral Science Foundation (Grant No. 2021M692266).
Publisher Copyright:
© The Author(s) 2022.
PY - 2022
Y1 - 2022
N2 - Microglia are critical players in the neuroimmune system, and their involvement in Alzheimer’s disease (AD) pathogenesis is increasingly being recognized. However, whether microglia play a positive or negative role in AD remains largely controversial and the precise molecular targets for intervention are not well defined. This partly results from the opposing roles of microglia in AD pathology, and is mainly reflected in the microglia-neuron interaction. Microglia can prune synapses resulting in excessive synapse loss and neuronal dysfunction, but they can also promote synapse formation, enhancing neural network plasticity. Neuroimmune crosstalk accelerates microglial activation, which induces neuron death and enhances the microglial phagocytosis of β-amyloid to protect neurons. Moreover, microglia have dual opposing roles in developing the major pathological features in AD, such as amyloid deposition and blood-brain barrier permeability. This review summarizes the dual opposing role of microglia in AD from the perspective of the interaction between neurons and microglia. Additionally, current AD treatments targeting microglia and the advantages and disadvantages of developing microglia-targeted therapeutic strategies are discussed.
AB - Microglia are critical players in the neuroimmune system, and their involvement in Alzheimer’s disease (AD) pathogenesis is increasingly being recognized. However, whether microglia play a positive or negative role in AD remains largely controversial and the precise molecular targets for intervention are not well defined. This partly results from the opposing roles of microglia in AD pathology, and is mainly reflected in the microglia-neuron interaction. Microglia can prune synapses resulting in excessive synapse loss and neuronal dysfunction, but they can also promote synapse formation, enhancing neural network plasticity. Neuroimmune crosstalk accelerates microglial activation, which induces neuron death and enhances the microglial phagocytosis of β-amyloid to protect neurons. Moreover, microglia have dual opposing roles in developing the major pathological features in AD, such as amyloid deposition and blood-brain barrier permeability. This review summarizes the dual opposing role of microglia in AD from the perspective of the interaction between neurons and microglia. Additionally, current AD treatments targeting microglia and the advantages and disadvantages of developing microglia-targeted therapeutic strategies are discussed.
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U2 - 10.1177/10738584211070273
DO - 10.1177/10738584211070273
M3 - Review article
C2 - 35348415
AN - SCOPUS:85127819056
SN - 1073-8584
VL - 29
SP - 616
EP - 638
JO - Neuroscientist
JF - Neuroscientist
IS - 5
ER -