TY - JOUR
T1 - The Differential Impact of Body Mass Index and the Feature of Metabolic Syndrome on Oncological Outcomes Following Different Surgical Procedures in Japanese Men with Prostate Cancer
AU - Shiota, Masaki
AU - Takeuchi, Ario
AU - Sugimoto, Masaaki
AU - Kashiwagi, Eiji
AU - Dejima, Takashi
AU - Kiyoshima, Keijiro
AU - Inokuchi, Junichi
AU - Tatsugami, Katsunori
AU - Yokomizo, Akira
AU - Eto, Masatoshi
N1 - Funding Information:
This work was supported by a Research Promotion Grant from the Daiwa Securities Health Foundation, Japan, and a Research Promotion Grant from the Smoking Research Foundation, Japan.
Publisher Copyright:
© 2016, Society of Surgical Oncology.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Purpose: This study aimed to examine the differential impact of body mass index and the feature of metabolic syndrome (MetS; obesity, hypertension, diabetes mellitus, and dyslipidemia) on biochemical recurrence (BCR) following radical prostatectomy (RP) treatment for prostate cancer using different surgical procedures. Methods: This study included 283 Japanese patients with clinically localized prostate cancer who were treated with RP between 2008 and 2012. The prognostic significance of overweight and the feature of MetS were analyzed according to surgical procedures. Results: BCR occurred in 68/283 (24.0%) men. Overweight and the feature of MetS were predictors of BCR in patients who had undergone open RP (ORP), but not in those treated with laparoscopic surgery. Multivariate analyses incorporating preoperative and postoperative risk factors revealed that overweight and the feature of MetS were independent BCR risk factors when treated with ORP. Conclusions: In Japanese men, overweight and the feature of MetS were associated with worse outcomes following RP, particularly ORP, compared with those following laparoscopic surgery. These results suggest that laparoscopic surgery can overcome the surgical challenges associated with abdominal obesity.
AB - Purpose: This study aimed to examine the differential impact of body mass index and the feature of metabolic syndrome (MetS; obesity, hypertension, diabetes mellitus, and dyslipidemia) on biochemical recurrence (BCR) following radical prostatectomy (RP) treatment for prostate cancer using different surgical procedures. Methods: This study included 283 Japanese patients with clinically localized prostate cancer who were treated with RP between 2008 and 2012. The prognostic significance of overweight and the feature of MetS were analyzed according to surgical procedures. Results: BCR occurred in 68/283 (24.0%) men. Overweight and the feature of MetS were predictors of BCR in patients who had undergone open RP (ORP), but not in those treated with laparoscopic surgery. Multivariate analyses incorporating preoperative and postoperative risk factors revealed that overweight and the feature of MetS were independent BCR risk factors when treated with ORP. Conclusions: In Japanese men, overweight and the feature of MetS were associated with worse outcomes following RP, particularly ORP, compared with those following laparoscopic surgery. These results suggest that laparoscopic surgery can overcome the surgical challenges associated with abdominal obesity.
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U2 - 10.1245/s10434-016-5705-2
DO - 10.1245/s10434-016-5705-2
M3 - Article
C2 - 27896516
AN - SCOPUS:84997610586
SN - 1068-9265
VL - 24
SP - 1443
EP - 1450
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 5
ER -
