The design of two different structural scaffolds using β-tricalcium phosphate (β-TCP) and collagen for bone tissue engineering

Takaaki Arahira, Mitsugu Todo

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    In the field of bone regeneration, regenerated bone graft has been the most primary concern rather than autografts and allografts. A regenerated bone graft may be developed by culturing and differentiating mesenchymal stem cells (MSCs) in a porous scaffold. In this chapter, two different structural scaffolds were fabricated using β-TCP and collagen. One is a collagen-based scaffold with β-TCP particles fabricated using freeze-drying methods. A collagen/β-TCP scaffold is known as a “particle distributed scaffold.” The other is a β-TCP-based scaffold with porous collagen structure fabricated using the polyurethane template method and a subsequent freeze-drying method. A β-TCP/collagen scaffold is known as a “two phase structural scaffold.” Rat bone marrow MSCs were cultured in two different structural composite scaffolds for up to 28 days in order to evaluate the time-dependent behavior of the extracellular matrix formation and the mechanical characteristic of the scaffold-cell system.

    Original languageEnglish
    Title of host publicationMaterials for Biomedical Engineering
    Subtitle of host publicationHydrogels and Polymer-based Scaffolds
    PublisherElsevier
    Pages371-401
    Number of pages31
    ISBN (Electronic)9780128169018
    DOIs
    Publication statusPublished - Jan 1 2019

    All Science Journal Classification (ASJC) codes

    • General Medicine
    • General Biochemistry,Genetics and Molecular Biology

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