The design of antimicrobial peptides based on the novel concept

Yoshinao Yamada, Yoshiko Miura, Kazukiyo Kobayashi

Research output: Contribution to conferencePaperpeer-review


Recently, we have developed a new type of antimicrobial peptides based on nuclear localization signal (NLS) sequences. We also have found that a globotriaosyl (Gb3) mimic peptide bound Shiga toxins strongly and neutralized the toxins effectively. The present paper proposes the design of tandem fusion peptides between NLS peptides and Gb3 mimic peptides. The tandem fusion peptides expressed multifunctions of both antimicrobial and Stx neutralization activities. The antimicrobial activity of the NLS peptide has been strongly enhanced by combining the Gb3 mimic sequence to its N-terminal. This proposed fusion peptides are expected to destroy bacteria and neutralize the released toxins simultaneously.

Original languageEnglish
Number of pages2
Publication statusPublished - Dec 1 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sept 20 2005Sept 22 2005


Other54th SPSJ Symposium on Macromolecules

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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