Recently, we have developed a new type of antimicrobial peptides based on nuclear localization signal (NLS) sequences. We also have found that a globotriaosyl (Gb3) mimic peptide bound Shiga toxins strongly and neutralized the toxins effectively. The present paper proposes the design of tandem fusion peptides between NLS peptides and Gb3 mimic peptides. The tandem fusion peptides expressed multifunctions of both antimicrobial and Stx neutralization activities. The antimicrobial activity of the NLS peptide has been strongly enhanced by combining the Gb3 mimic sequence to its N-terminal. This proposed fusion peptides are expected to destroy bacteria and neutralize the released toxins simultaneously.
|Number of pages||2|
|Publication status||Published - Dec 1 2005|
|Event||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|
Duration: Sept 20 2005 → Sept 22 2005
|Other||54th SPSJ Symposium on Macromolecules|
|Period||9/20/05 → 9/22/05|
All Science Journal Classification (ASJC) codes