TY - JOUR
T1 - The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events
AU - Maeda, Toyoki
AU - Oyama, Jun Ichi
AU - Higuchi, Yoshihiro
AU - Koyanagi, Masamichi
AU - Sasaki, Makoto
AU - Arima, Takahiro
AU - Mimori, Koshi
AU - Makino, Naoki
N1 - Funding Information:
This work was supported, in part, by a Grant-in-Aid from the Ministry of Education, Science, and Culture of Japan (#20590703).
PY - 2011/3
Y1 - 2011/3
N2 - The telomere length and subtelomeric methylated status of peripheral blood leukocytes has been reported to be correlated with many kinds of pathophysiological conditions. However, the correlation between the telomeric parameters and clinical laboratory data in metabolic disorders is not well known. This study investigated the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of male outpatients with combined metabolic disorders and no clinical history of cardiovascular or cerebrovascular event were assessed, to find good clinical laboratory markers reflecting the biological aging. The laboratory data were collected in 26 Japanese male outpatients with diabetes mellitus and hyperlipidemia, and no history of cardiovascular or cerebrovascular event, and the telomeric parameters in their peripheral leukocytes were determined by Southern blot with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. The patients showed a significant negative correlation among the bilirubin and creatine phosphokinase with the aging-associate change of the telomeric and subtelomeric parameters. Lowered serum bilirubin and creatinine phosphokinase level correlated to genomic aging represented by telomere attrition of patients with metabolic disorders.
AB - The telomere length and subtelomeric methylated status of peripheral blood leukocytes has been reported to be correlated with many kinds of pathophysiological conditions. However, the correlation between the telomeric parameters and clinical laboratory data in metabolic disorders is not well known. This study investigated the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of male outpatients with combined metabolic disorders and no clinical history of cardiovascular or cerebrovascular event were assessed, to find good clinical laboratory markers reflecting the biological aging. The laboratory data were collected in 26 Japanese male outpatients with diabetes mellitus and hyperlipidemia, and no history of cardiovascular or cerebrovascular event, and the telomeric parameters in their peripheral leukocytes were determined by Southern blot with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. The patients showed a significant negative correlation among the bilirubin and creatine phosphokinase with the aging-associate change of the telomeric and subtelomeric parameters. Lowered serum bilirubin and creatinine phosphokinase level correlated to genomic aging represented by telomere attrition of patients with metabolic disorders.
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U2 - 10.3109/13685538.2010.502270
DO - 10.3109/13685538.2010.502270
M3 - Article
C2 - 20670100
AN - SCOPUS:79751483156
SN - 1368-5538
VL - 14
SP - 21
EP - 26
JO - Aging Male
JF - Aging Male
IS - 1
ER -
