The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery

A. Tsuchiya; T. Mori; Y. Naritomi; J. H. Kang; D. Asai; T. Niidome; Y. Endo; R. Suzuki; Y. Negishi; K. Maruyama; Y. Katayama

The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery

A. Tsuchiya, T. Mori, Y. Naritomi, J. H. Kang, D. Asai, T. Niidome, Y. Endo, R. Suzuki, Y. Negishi, K. Maruyama, Y. Katayama

Oral Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.

Original language	English
Title of host publication	Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges
Pages	7-11
Number of pages	5
Publication status	Published - 2010
Event	2009 MRS Fall Meeting - Boston, MA, United States Duration: Nov 30 2009 → Dec 2 2009

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1237
ISSN (Print)	0272-9172

Other

Other	2009 MRS Fall Meeting
Country/Territory	United States
City	Boston, MA
Period	11/30/09 → 12/2/09

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

Tsuchiya, A., Mori, T., Naritomi, Y., Kang, J. H., Asai, D., Niidome, T., Endo, Y., Suzuki, R., Negishi, Y., Maruyama, K., & Katayama, Y. (2010). The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery. In Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges (pp. 7-11). (Materials Research Society Symposium Proceedings; Vol. 1237).

The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery. / Tsuchiya, A.; Mori, T.; Naritomi, Y. et al.
Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges. 2010. p. 7-11 (Materials Research Society Symposium Proceedings; Vol. 1237).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tsuchiya, A , Mori, T, Naritomi, Y, Kang, JH, Asai, D, Niidome, T, Endo, Y, Suzuki, R, Negishi, Y, Maruyama, K & Katayama, Y 2010, The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery. in Nanobiotechnology and Nanobiophotonics - Opportunities and Challenges. Materials Research Society Symposium Proceedings, vol. 1237, pp. 7-11, 2009 MRS Fall Meeting, Boston, MA, United States, 11/30/09.

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abstract = "We have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.",

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AU - Tsuchiya, A.

AU - Mori, T.

AU - Naritomi, Y.

AU - Kang, J. H.

AU - Asai, D.

AU - Niidome, T.

AU - Endo, Y.

AU - Suzuki, R.

AU - Negishi, Y.

AU - Maruyama, K.

AU - Katayama, Y.

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N2 - We have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.

AB - We have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.

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The combination of drug or gene delivery system responding to cellular signals (D-RECS) and sonoporation system for effective and safe gene delivery

Abstract

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Other

All Science Journal Classification (ASJC) codes

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