@article{43f90628007b4dd580de1de148aecf74,
title = "The CCL20 and CCR6 axis in psoriasis",
abstract = "Psoriasis is a TNF-α/IL-23/IL-17A–mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A–producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A–rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.",
author = "Kazuhisa Furue and Takamichi Ito and Gaku Tsuji and Takeshi Nakahara and Masutaka Furue",
note = "Funding Information: Psoriasis is a TNF‐α/IL‐23/IL‐17A–mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL‐17A–producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL‐17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL‐17A–rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis. Funding information This work was partly supported by grants from The Ministry of Health, Labour and Welfare in Japan (H30‐Shokuhin‐Shitei‐005) and by The Leading Advanced Projects for Medical Innovation in Japan (LEAP). Publisher Copyright: {\textcopyright} 2019 The Scandinavian Foundation for Immunology",
year = "2020",
month = mar,
day = "1",
doi = "10.1111/sji.12846",
language = "English",
volume = "91",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "3",
}