The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition

Chie Kikutake; Masaaki Shinohara; Hisanori Takagi; Takashi Nakashima; Makoto Kimura

doi:10.1271/bbb.90485

The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition

Chie Kikutake, Masaaki Shinohara, Hisanori Takagi, Takashi Nakashima, Makoto Kimura

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.

Original language	English
Pages (from-to)	2766-2768
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	12
DOIs	https://doi.org/10.1271/bbb.90485
Publication status	Published - 2009

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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abstract = "Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.",

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AU - Takagi, Hisanori

AU - Nakashima, Takashi

AU - Kimura, Makoto

PY - 2009

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AB - Mutations of amino acids in the C-terminal region of an archaeal toxin, aRelE, from Pyrococcus horikoshii were characterized with respect to protein synthesis inhibitory activity and 70S ribosome-binding activity. The results suggest that basic residues at the C-terminal region in aRelE play a crucial role both in 70S ribosome binding and in protein synthesis inhibition activities.

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The C-terminal portion of an archaeal toxin, aRelE, plays a crucial role in protein synthesis inhibition

Abstract

All Science Journal Classification (ASJC) codes

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