TY - JOUR
T1 - The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats
AU - Katafuchi, Toshihiko
AU - Okada, Eiichiro
AU - Take, Sachiko
AU - Hori, Tetsuro
N1 - Funding Information:
We thank Dr. B.T. Quinn, Kyushu University, for reading the manuscript. This work was supported in part by Grants-in-Aid for General Scientific Research (05454143 to T.K. and 04454144 to T.H.) from the Ministry of Education, Science, and Culture, Japan, and by Special Coordination Funds of the Science and Technology Agency of the Japanese Government (to T.H.).
PY - 1994/7/25
Y1 - 1994/7/25
N2 - The cytotoxic activity of natural killer (NK) cells in the spleen was measured by a standard 4-h chromium release assay following electrical lesioning of the ventromedial hypothalamic nucleus (VMH) in rats. The splenic NK cell activity of VMH lesioned rats was found to be significantly suppressed at effector: target cell ratios of 100:1 and 50:1 compared with that of sham lesioned rats on day 4 after the lesion. On the other hand, on day 49, the VMH lesioned animals that had become hyperphagic and obese showed an enhancement of splenic NK cell activity compared with sham lesioned animals. The mechanisms of the biphasic change in NK cell activity following the VMH lesions are discussed.
AB - The cytotoxic activity of natural killer (NK) cells in the spleen was measured by a standard 4-h chromium release assay following electrical lesioning of the ventromedial hypothalamic nucleus (VMH) in rats. The splenic NK cell activity of VMH lesioned rats was found to be significantly suppressed at effector: target cell ratios of 100:1 and 50:1 compared with that of sham lesioned rats on day 4 after the lesion. On the other hand, on day 49, the VMH lesioned animals that had become hyperphagic and obese showed an enhancement of splenic NK cell activity compared with sham lesioned animals. The mechanisms of the biphasic change in NK cell activity following the VMH lesions are discussed.
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U2 - 10.1016/0006-8993(94)90333-6
DO - 10.1016/0006-8993(94)90333-6
M3 - Article
C2 - 7953716
AN - SCOPUS:0028335550
SN - 0006-8993
VL - 652
SP - 164
EP - 168
JO - Brain Research
JF - Brain Research
IS - 1
ER -