The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

Hikarua Takeuchi; Yasuyuki Taki; Rui Nouchi; Ryoichi Yokoyama; Seishu Nakagawa; Kunio Iizuka; Kohei Sakaki; Tsuyoshi Araki; Takayuki Nozawa; Shigeyuki Ikeda; Susumu Yokota; Sugiko Hanawa; Daniele Magistro; Yuka Kotozaki; Yukako Sasaki; Kelssy H. Kelssy; Ryuta Kawashima

doi:10.1038/s41598-020-69438-5

The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

Hikarua Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Seishu Nakagawa, Kunio Iizuka, Kohei Sakaki, Tsuyoshi Araki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Sugiko Hanawa, Daniele Magistro, Yuka Kotozaki, Yukako Sasaki, Kelssy H. Kelssy, Ryuta Kawashima

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.

Original language	English
Article number	12566
Journal	Scientific reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-69438-5
Publication status	Published - Dec 1 2020
Externally published	Yes

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Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Nakagawa, S., Iizuka, K., Sakaki, K., Araki, T., Nozawa, T., Ikeda, S., Yokota, S., Hanawa, S., Magistro, D., Kotozaki, Y., Sasaki, Y., Kelssy, K. H., & Kawashima, R. (2020). The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity. Scientific reports, 10(1), Article 12566. https://doi.org/10.1038/s41598-020-69438-5

Takeuchi, H, Taki, Y, Nouchi, R, Yokoyama, R, Nakagawa, S, Iizuka, K, Sakaki, K, Araki, T, Nozawa, T, Ikeda, S, Yokota, S, Hanawa, S, Magistro, D, Kotozaki, Y, Sasaki, Y, Kelssy, KH & Kawashima, R 2020, 'The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity', Scientific reports, vol. 10, no. 1, 12566. https://doi.org/10.1038/s41598-020-69438-5

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abstract = "Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.",

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note = "Funding Information: We respectfully thank Yuki Yamada for operating the MRI scanner. We also thank the study participants, other examiners of the psychological tests, and all of our colleagues at the Institute of Development, Aging and Cancer and Tohoku University for their support. The authors would like to thank Enago (www.enago.jp) for the English language review. This study was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. Publisher Copyright: {\textcopyright} 2020, The Author(s).",

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AU - Nouchi, Rui

AU - Yokoyama, Ryoichi

AU - Nakagawa, Seishu

AU - Iizuka, Kunio

AU - Sakaki, Kohei

AU - Araki, Tsuyoshi

AU - Nozawa, Takayuki

AU - Ikeda, Shigeyuki

AU - Yokota, Susumu

AU - Hanawa, Sugiko

AU - Magistro, Daniele

AU - Kotozaki, Yuka

AU - Sasaki, Yukako

AU - Kelssy, Kelssy H.

AU - Kawashima, Ryuta

N1 - Funding Information: We respectfully thank Yuki Yamada for operating the MRI scanner. We also thank the study participants, other examiners of the psychological tests, and all of our colleagues at the Institute of Development, Aging and Cancer and Tohoku University for their support. The authors would like to thank Enago (www.enago.jp) for the English language review. This study was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. Publisher Copyright: © 2020, The Author(s).

PY - 2020/12/1

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N2 - Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI < 40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.

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The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

Abstract

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UN SDGs

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