The 5α-reductase inhibitory components from heartwood of Artocarpus incisus: Structure-activity investigations

Kuniyoshi Shimizu, Masayuki Fukuda, Ryuichiro Kondo, Kokki Sakai

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

The methanol extract of heartwood of Artocarpus incisus showed potent 5α-reductase inhibitory activity. We investigated the 5α-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 μM) and artocarpin (IC50 = 85 μM) showed more potent inhibitory effects than did α-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5α-reductase inhibitory effects.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalPlanta medica
Volume66
Issue number1
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Analytical Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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