TY - JOUR
T1 - Th1 and Th1-inducing cytokines in Salmonella infection
AU - Mizuno, Yumi
AU - Takada, H.
AU - Nomura, A.
AU - Jin, C. H.
AU - Hattori, H.
AU - Ihara, K.
AU - Aoki, T.
AU - Eguchi, K.
AU - Hara, T.
PY - 2003
Y1 - 2003
N2 - Thl and Thl-inducing cytokines and T cell responses were investigated in human salmonellosis. Serum IFN-γ, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis. The increase in serum IL-15 and IL-18 levels was more significant and prolonged in patients with the systemic form of salmonellosis than in those with the gastroenteric form. The serum IFN-γ level was correlated significantly with IL-12 and IL18 levels, and the IL-15 level was correlated significantly with IL-18. Upon stimulation with Salmonella in vitro, mononuclear cells from salmonellosis patients produced significantly higher amounts of IFN-γ and IL-12 compared with those from healthy controls. Anti-IL-12 moAb or anti-IL18 MoAb significantly inhibited Salmonella-induced IFN-γ production in vitro. γδ T cells expressed significantly higher levels of IFN-γmRNA in salmonellosis patients than in healthy controls. The results suggest that Th1-inducing cytokines appear to be involved in the in vivo response against Salmonella infection, promoting IFN-γ production by αβ and γδ T cells which plays a protective role against Salmonella.
AB - Thl and Thl-inducing cytokines and T cell responses were investigated in human salmonellosis. Serum IFN-γ, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis. The increase in serum IL-15 and IL-18 levels was more significant and prolonged in patients with the systemic form of salmonellosis than in those with the gastroenteric form. The serum IFN-γ level was correlated significantly with IL-12 and IL18 levels, and the IL-15 level was correlated significantly with IL-18. Upon stimulation with Salmonella in vitro, mononuclear cells from salmonellosis patients produced significantly higher amounts of IFN-γ and IL-12 compared with those from healthy controls. Anti-IL-12 moAb or anti-IL18 MoAb significantly inhibited Salmonella-induced IFN-γ production in vitro. γδ T cells expressed significantly higher levels of IFN-γmRNA in salmonellosis patients than in healthy controls. The results suggest that Th1-inducing cytokines appear to be involved in the in vivo response against Salmonella infection, promoting IFN-γ production by αβ and γδ T cells which plays a protective role against Salmonella.
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U2 - 10.1046/j.1365-2249.2003.02060.x
DO - 10.1046/j.1365-2249.2003.02060.x
M3 - Article
C2 - 12519393
AN - SCOPUS:0037232367
SN - 0009-9104
VL - 131
SP - 111
EP - 117
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 1
ER -
