Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series

Shigesato Inoue; Hiroaki Ogata; Yoichi Dotake; Koichi Takagi; Ayaka Shiota; Yumiko Ishii; Kentaro Tanaka; Keiko Kano; Hiromasa Inoue

doi:10.1016/j.jacig.2025.100448

Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series

Shigesato Inoue, Hiroaki Ogata, Yoichi Dotake, Koichi Takagi, Ayaka Shiota, Yumiko Ishii, Kentaro Tanaka, Keiko Kano, Hiromasa Inoue

Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions after receiving tezepelumab treatment are presented.

Original language	English
Article number	100448
Journal	Journal of Allergy and Clinical Immunology: Global
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jacig.2025.100448
Publication status	Published - May 2025

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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10.1016/j.jacig.2025.100448

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title = "Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series",

abstract = "Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions after receiving tezepelumab treatment are presented.",

keywords = "Asthma control, nasal polyps, rhinosinusitis, severe asthma, tezepelumab",

author = "Shigesato Inoue and Hiroaki Ogata and Yoichi Dotake and Koichi Takagi and Ayaka Shiota and Yumiko Ishii and Kentaro Tanaka and Keiko Kano and Hiromasa Inoue",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s)",

year = "2025",

month = may,

doi = "10.1016/j.jacig.2025.100448",

language = "English",

volume = "4",

journal = "Journal of Allergy and Clinical Immunology: Global",

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T1 - Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis

T2 - Case series

AU - Inoue, Shigesato

AU - Ogata, Hiroaki

AU - Dotake, Yoichi

AU - Takagi, Koichi

AU - Shiota, Ayaka

AU - Ishii, Yumiko

AU - Tanaka, Kentaro

AU - Kano, Keiko

AU - Inoue, Hiromasa

PY - 2025/5

Y1 - 2025/5

N2 - Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions after receiving tezepelumab treatment are presented.

AB - Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions after receiving tezepelumab treatment are presented.

KW - Asthma control

KW - nasal polyps

KW - rhinosinusitis

KW - severe asthma

KW - tezepelumab

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M3 - Article

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SN - 2772-8293

VL - 4

JO - Journal of Allergy and Clinical Immunology: Global

JF - Journal of Allergy and Clinical Immunology: Global

IS - 2

M1 - 100448

ER -

Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series

Abstract

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