Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

Minoru Omura; Miyuki Hirata; Akiyo Tanaka; Mangen Zhao; Yuji Makita; Naohide Inoue; Kaoru Gotoh; Noburu Ishinishi

doi:10.1016/S0378-4274(96)03796-4

Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

Minoru Omura
, Miyuki Hirata
, Akiyo Tanaka
, Mangen Zhao
, Yuji Makita
, Naohide Inoue
, Kaoru Gotoh
, Noburu Ishinishi

Social Medicine

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As₂O₃) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As₂O₃ (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As₂O₃ did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As₂O₃-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	Toxicology Letters
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/S0378-4274(96)03796-4
Publication status	Published - Dec 16 1996

All Science Journal Classification (ASJC) codes

Toxicology

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10.1016/S0378-4274(96)03796-4

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title = "Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters",

abstract = "The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.",

keywords = "Arsenic oxide, Gallium arsenide, Hamster, Indium arsenide, Intratracheal instillation, Testicular toxicity",

author = "Minoru Omura and Miyuki Hirata and Akiyo Tanaka and Mangen Zhao and Yuji Makita and Naohide Inoue and Kaoru Gotoh and Noburu Ishinishi",

note = "Funding Information: The authors thank Kazuto Honda of Perkin-Elmer Japan for elemental analysis with ICP-MS. We also thank Ms. Yoshiko Hirose for her technical assistance. This study was partly supported by Grants No. 07670405 and No. 07307006 from the Ministry of Education, Science and Culture, Japan.",

year = "1996",

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doi = "10.1016/S0378-4274(96)03796-4",

language = "English",

volume = "89",

pages = "123--129",

journal = "Toxicology Letters",

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TY - JOUR

T1 - Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

AU - Omura, Minoru

AU - Hirata, Miyuki

AU - Tanaka, Akiyo

AU - Zhao, Mangen

AU - Makita, Yuji

AU - Inoue, Naohide

AU - Gotoh, Kaoru

AU - Ishinishi, Noburu

N1 - Funding Information: The authors thank Kazuto Honda of Perkin-Elmer Japan for elemental analysis with ICP-MS. We also thank Ms. Yoshiko Hirose for her technical assistance. This study was partly supported by Grants No. 07670405 and No. 07307006 from the Ministry of Education, Science and Culture, Japan.

PY - 1996/12/16

Y1 - 1996/12/16

N2 - The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

AB - The testicular toxicities of gallium arsenide (GaAs), indium arsenide (InAs) and arsenic trioxide (As2O3) were examined by repetitive intratracheal instillation using hamsters. GaAs (7.7 mg/kg) and As2O3 (1.3 mg/kg) were instilled twice a week a total of 16 times and InAs (7.7 mg/kg) was instilled a total of 14 times. GaAs caused testicular spermatid retention and epididymal sperm reduction, though the degrees were less severe than those in rats shown in our previous experiment. InAs and As2O3 did not show any testicular toxicities. Serum arsenic concentration in GaAs-treated hamsters was less than half of that in As2O3-treated hamsters in which no testicular toxicities were found. Serum molar concentration of gallium was 32-times higher than that of arsenic in GaAs-treated hamsters. Therefore gallium may play a main role in the testicular toxicity of GaAs in hamsters.

KW - Arsenic oxide

KW - Gallium arsenide

KW - Hamster

KW - Indium arsenide

KW - Intratracheal instillation

KW - Testicular toxicity

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ER -

Testicular toxicity evaluation of arsenic-containing binary compound semiconductors, gallium arsenide and indium arsenide, in hamsters

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