Temperature-responsive "catch and release" of proteins by using multifunctional polymer-based nanoparticles

Keiichi Yoshimatsu; Benjamin K. Lesel; Yusuke Yonamine; John M. Beierle; Yu Hoshino; Kenneth J. Shea

doi:10.1002/anie.201107797

Temperature-responsive "catch and release" of proteins by using multifunctional polymer-based nanoparticles

Keiichi Yoshimatsu
, Benjamin K. Lesel
, Yusuke Yonamine
, John M. Beierle
, Yu Hoshino
, Kenneth J. Shea

Molecular and Biochemical Systems Engineering

Research output: Contribution to journal › Article › peer-review

154 Citations (Scopus)

Abstract

Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive "catch-and-release" of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.

Original language	English
Pages (from-to)	2405-2408
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	10
DOIs	https://doi.org/10.1002/anie.201107797
Publication status	Published - Mar 5 2012

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry

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10.1002/anie.201107797

Cite this

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abstract = "Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive {"}catch-and-release{"} of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.",

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AU - Beierle, John M.

AU - Hoshino, Yu

AU - Shea, Kenneth J.

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AB - Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive "catch-and-release" of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.

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Temperature-responsive "catch and release" of proteins by using multifunctional polymer-based nanoparticles

Abstract

All Science Journal Classification (ASJC) codes

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