Telomerase inhibiting activity in vitro from natural resources, marine algae extracts

Kazunori Kanegawa; Hideki Harada; Hisashi Myouga; Yoshinori Katakura; Sanetaka Shirahata; Yuto Kamei

doi:10.1023/a:1008179302906

Telomerase inhibiting activity in vitro from natural resources, marine algae extracts

Kazunori Kanegawa, Hideki Harada, Hisashi Myouga, Yoshinori Katakura, Sanetaka Shirahata, Yuto Kamei

Systems Biology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We attempted to screen for telomerase inhibiting activity in vitro from a total of 304 marine algae samples which were collected from various Japan coasts by nonradioisotope telomeric repeat amplification protocol (Non-RI TRAP) assay using human leukemia MOLT-4 cells. Ten of the MeOH extracts and two of the PBS extracts from those algal samples showed telomerase inhibiting activity. In particular, the MeOH extract from a green alga, Caulerpa sertularioides strongly inhibited telomerase activity when added to MOLT-4 cell culture at a level of 1.25% (v/v), suggesting that it may be possible to develop a novel anti-cancer agent in view of its specific anti-telomeric property.

Original language	English
Pages (from-to)	221-227
Number of pages	7
Journal	Cytotechnology
Volume	33
Issue number	1-3
DOIs	https://doi.org/10.1023/a:1008179302906
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "We attempted to screen for telomerase inhibiting activity in vitro from a total of 304 marine algae samples which were collected from various Japan coasts by nonradioisotope telomeric repeat amplification protocol (Non-RI TRAP) assay using human leukemia MOLT-4 cells. Ten of the MeOH extracts and two of the PBS extracts from those algal samples showed telomerase inhibiting activity. In particular, the MeOH extract from a green alga, Caulerpa sertularioides strongly inhibited telomerase activity when added to MOLT-4 cell culture at a level of 1.25% (v/v), suggesting that it may be possible to develop a novel anti-cancer agent in view of its specific anti-telomeric property.",

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T1 - Telomerase inhibiting activity in vitro from natural resources, marine algae extracts

AU - Kanegawa, Kazunori

AU - Harada, Hideki

AU - Myouga, Hisashi

AU - Katakura, Yoshinori

AU - Shirahata, Sanetaka

AU - Kamei, Yuto

PY - 2000

Y1 - 2000

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AB - We attempted to screen for telomerase inhibiting activity in vitro from a total of 304 marine algae samples which were collected from various Japan coasts by nonradioisotope telomeric repeat amplification protocol (Non-RI TRAP) assay using human leukemia MOLT-4 cells. Ten of the MeOH extracts and two of the PBS extracts from those algal samples showed telomerase inhibiting activity. In particular, the MeOH extract from a green alga, Caulerpa sertularioides strongly inhibited telomerase activity when added to MOLT-4 cell culture at a level of 1.25% (v/v), suggesting that it may be possible to develop a novel anti-cancer agent in view of its specific anti-telomeric property.

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Telomerase inhibiting activity in vitro from natural resources, marine algae extracts

Abstract

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