Taste preference for fatty acids is mediated by GPR40 and GPR120

Cristina Cartoni, Keiko Yasumatsu, Tadahiro Ohkuri, Noriatsu Shigemura, Ryusuke Yoshida, Nicolas Godinot, Johannes Le Coutre, Yuzo Ninomiya, Sami Damak

Research output: Contribution to journalArticlepeer-review

334 Citations (Scopus)


The oral perception of fat has traditionally been considered to rely mainly on texture and olfaction, but recent findings suggest that taste may also play a role in the detection of long chain fatty acids. The two G-protein coupled receptors GPR40 (Ffar1) and GPR120 are activated by medium and long chain fatty acids. Here we show that GPR120 and GPR40 are expressed in the taste buds, mainly in type II and type I cells, respectively. Compared with wild-type mice, male and female GPR120 knock-out and GPR40 knock-out mice show a diminished preference for linoleic acid and oleic acid, and diminished taste nerve responses to several fatty acids. These results show that GPR40 and GPR120 mediate the taste of fatty acids.

Original languageEnglish
Pages (from-to)8376-8382
Number of pages7
JournalJournal of Neuroscience
Issue number25
Publication statusPublished - Jun 23 2010

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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