Targeting the Hippo signalling pathway for cancer treatment

Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Hiroki Goto, Wakako Kato, Hirofumi Omori, Yosuke Miyachi, Hideru Togashi, Yohei Shimono, Akira Suzuki

    Research output: Contribution to journalReview articlepeer-review

    38 Citations (Scopus)


    The Hippo signalling pathway monitors cell-cell contact and external factors that shape tissue structure. In mice, tumourigenesis and developmental abnormalities are common consequences of dysregulated Hippo signalling. Expression of Hippo pathway components is also frequently altered in human tumours and correlates with poor prognosis and reduced patient survival. Thus, the Hippo pathway is an attractive anti-cancer target. Here, we provide an overview of the function and regulation of Hippo signalling components and summarize progress to date on the development of agents able to regulate Hippo signalling for cancer therapy.

    Original languageEnglish
    Pages (from-to)237-244
    Number of pages8
    JournalJournal of biochemistry
    Issue number3
    Publication statusPublished - 2017

    All Science Journal Classification (ASJC) codes

    • Medicine(all)


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