Tandemly repeated peptide for cancer-specific gene carrier prepared by native chemical ligation

Daiki Funamoto, Daisuke Asai, Chan Woo Kim, Yuta Nakamura, Eun Kyung Lee, Takanobu Nobori, Takuro Niidome, Takeshi Mori, Yoshiki Katayama

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    We reported here a preparation of a cancer-specific gene carrier by native chemical ligation of a substrate peptide of protein kinase Cα (PKCα), which highly expresses in many types of cancer. This carrier is a tetramer of the substrate peptide connected with adequate spacer to maintain reactivity toward PKCα. The carrier successfully regulated the reporter gene expression responding to the phosphorylation of its serine residues.

    Original languageEnglish
    Pages (from-to)474-476
    Number of pages3
    JournalChemistry Letters
    Volume44
    Issue number4
    DOIs
    Publication statusPublished - 2015

    All Science Journal Classification (ASJC) codes

    • General Chemistry

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