TY - JOUR
T1 - T cell immunity in hepatitis B and hepatitis C virus infection
T2 - Implications for autoimmunity
AU - Ichiki, Yasunori
AU - He, Xiao Song
AU - Shimoda, Shinji
AU - Ishibashi, Hiromi
AU - Keeffe, Emmet B.
AU - Rossaro, Lorenzo
AU - Gershwin, M. Eric
PY - 2005/2
Y1 - 2005/2
N2 - T cells are involved in the pathogenesis of important liver diseases including both autoimmune liver diseases and viral hepatitis. In addition to playing a crucial role in the control of hepatitis viruses, T cell responses are also responsible for the liver injury during acute and chronic phases of viral hepatitis. In this article, we reviewed current literature on T cell immunity to hepatitis B and C viruses. In addition, antigen presenting cells that are critical for T cell immunity against these viruses are also discussed. This will provide insights to the understanding of T cell immunity in autoimmune liver diseases due to the similar role of T cells in autoimmune liver diseases and viral hepatitis.
AB - T cells are involved in the pathogenesis of important liver diseases including both autoimmune liver diseases and viral hepatitis. In addition to playing a crucial role in the control of hepatitis viruses, T cell responses are also responsible for the liver injury during acute and chronic phases of viral hepatitis. In this article, we reviewed current literature on T cell immunity to hepatitis B and C viruses. In addition, antigen presenting cells that are critical for T cell immunity against these viruses are also discussed. This will provide insights to the understanding of T cell immunity in autoimmune liver diseases due to the similar role of T cells in autoimmune liver diseases and viral hepatitis.
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U2 - 10.1016/j.autrev.2004.12.003
DO - 10.1016/j.autrev.2004.12.003
M3 - Review article
C2 - 15722254
AN - SCOPUS:13844256575
SN - 1568-9972
VL - 4
SP - 82
EP - 95
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 2
ER -
